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There are various studies on the eco-innovation in the literature, but there is a scarcity of studies on the adoption and diffusion within manufacturing small and medium-size enterprises (SMEs). Drivers to adopt eco-innovations by manufacturing SMEs are required to be understood properly and be analyzed regarding the relationships among them. Hence, the purpose of this study is to identify the main drivers of eco-innovation adoption by Iranian manufacturing SMEs from the literature and further model them based on experts’ opinions. We have utilized the valuable opinions of experts to develop a hierarchical model of drivers utilizing Interpretive Structural Modeling approach to demonstrate the contextual interrelationship among these factors. Furthermore, degrees of relationships among the drivers were obtained according to Matrice d'Impacts Croises Multipication Applique´ an Classment analysis approach.  Identification and modeling of eco-innovation drivers is expected to assist managers of companies to develop policies and further prioritize them to facilitate eco-innovation adoption.